房新强,男,理学博士,研究员、课题组长、博士生导师。籍贯山东淄博。2005年硕士毕业于中国科学技术大学(指导教师:刘有成院士),2009年博士毕业于中国科学院上海有机化学研究所(指导教师:李超忠研究员);2009年至2013年从事海外博士后研究工作。2013年9月以高层次人才引进到中科院福建物质结构研究所,任研究员和课题组长。曾获国家高层次青年人才计划、中国科学院引才计划、福建省高层次创业创新人才项目。目前已发表研究论文58篇,受邀撰写专著一章,获得授权专利3件,主持国家和省级科学等各类基金项目15项。
研究方向:有机合成方法学,不对称催化,新反应模式、新合成策略、新研究领域的开发和应用、天然产物和药物活性分子的合成
招生专业:有机化学
电子邮件:xqfang@fjirsm.ac.cn
联系电话: 0591-63173513
办公室地址:海西院新区1号楼1313
课题组介绍:http://www.fjirsm.cas.cn/fangxinqiang/
课题组位于海西院新区,依托结构化学国家重点实验室和煤制乙二醇及相关技术中科院重点实验室开展工作。课题组拥有充裕的实验室面积和齐全的各类仪器设备。课题组成员共同组成了一支包含硕士/博士/博士后/副研究员/研究员的拼搏向上的科研队伍;课题组制定了多种奖励措施鼓励勤奋进取的学生,并与国内外多个知名课题组建立了广泛的交流合作,为有志于进一步深造的优秀学生提供良好的支持。欢迎热爱有机化学的优秀人才加入我们课题组,锐意进取,共攀高峰!
代表性研究成果:
1. Copper-Catalyzed Skeletal Rearrangement of Cyclic Ethynylethylene Carbonates: Synthetic Applications and Mechanistic Studies, Hao Zhang,§ Chao Xu,§ Shouang Lan, Jinggong Liu, Shuang Yang, Qi Zhang,* and Xinqiang Fang,* Angew. Chem. Int. Ed. 2023, 10.1002/anie.202219064.
2. Dynamic Kinetic Resolution of β-Substituted α-Diketones via Asymmetric Transfer Hydrogenation, Ting Chen,§ Wenjun Liu,§ Wei Gu, Shengtong Niu, Shouang Lan, Zhifei Zhao, Fan Gong, Jinggong Liu, Shuang Yang, Andrej Emanuel Cotman, Jinshuai Song,* Xinqiang Fang,* J. Am. Chem. Soc. 2023, 145, 585?599.
3. Asymmetric Semipinacol Rearrangement Enabled by Copper-Catalyzed Propargylic Alkylation, Fan Gong,§ Xiangjian Meng,§ Shouang Lan, Jinggong Liu, Shuang Yang, Xinqiang Fang,* ACS Catal. 2022, 12, 12036?12044.
4. Copper-Catalyzed Yne-Allylic Substitutions Using Stabilized Nucleophiles, Shengtong Niu, Yingkun Luo, Chao Xu, Jinggong Liu, Shuang Yang, Xinqiang Fang,* ACS Catal. 2022, 12, 6840–6850.
5. Organocatalyzed Trifunctionalization of Alkynyl 1,2-Diones for the Concise Synthesis of Acyloxy Allylidene Malonates and γ-Alkylidenebutenolides, Li Chen, Shengtong Niu, Shouang Lan, Wenjun Liu, Shuang Yang,* Xinqiang Fang,* Green Chem. 2022, 24, 3623–3628.
6. Access to Enantioenriched Compounds Bearing Challenging Tetrasubstituted Stereocenters via Kinetic Resolution of Auxiliary Adjacent Alcohols, Shengtong Niu,? Hao Zhang,? Weici Xu,* Prasanta Ray Bagdi, Guoxiang Zhang, Jinggong Liu, Shuang Yang, and Xinqiang Fang,* Nature Commun. 2021, 12: 3735.
7. Catalytic chemodivergent annulations between α-diketones and alkynyl α-diketones, Xiangwen Kong, Fang Yu, Zhizhou Chen, Fan Gong, Shuang Yang, Jinggong Liu, Benlong Luo, Xinqiang Fang,* Sci. China Chem. 2021, 64, 991?998.
8. Organocatalyzed Kinetic Resolution of a-Functionalized Ketones: the Malonate Unit Leads the Way, Jian Liu, Laxmaiah Vasamsetty, Muhammad Anwar, Shuang Yang,* Weici Xu, Jinggong Liu, Sakkani Nagaraju, and Xinqiang Fang,* ACS Catal. 2020, 10, 2882-2893.
9. A Genetically Encoded Allysine for the Synthesis of Proteins with Site-Specific Lysine Dimethylation, Zhipeng A. Wang, Yu Zeng, Yadagiri Kurra, Xin Wang, Jeffery M. Tharp, Erol C. Vatansever, Willie W. Hsu, Susie Dai, Xinqiang Fang,* and Wenshe R. Liu,* Angew. Chem., Int. Ed. 2017, 56, 212-216.
10. Dynamic Kinetic Resolution Enabled by Intramolecular Benzoin Reaction: Synthetic Applications and Mechanistic Insights, Guoxiang Zhang, Shuang Yang, Xiaoyan Zhang, Qiqiao Lin, Deb K. Das, Jian Liu, and Xinqiang Fang,* J. Am. Chem. Soc. 2016, 138, 7932-7938.