Chirality is one of the fundamental properties of nature. Biological components such as DNA and proteins are chiral;chiral compounds,including chiral pharmaceuticals,play an increasingly vital role in human society. Asymmetric catalysis serves as a crucial pathway for obtaining chiral compounds,including chiral drugs,and represents one of the most active and challenging frontiers in contemporary organic chemistry research.

Our research group focuses on asymmetric catalysis and drug synthesis,with a particular emphasis on catalytic transformations involving multisite carbonyl molecules. We have sequentially developed three research directions: (1) kinetic resolution of multisite ketone molecules;(2) highly selective transformations of 1,2-dicarbonyl compounds;and (3) development of novel reaction modes for multisite esters. We prioritize the summarization of empirical regularities while pursuing innovation and breakthroughs. With a strong emphasis on methodological generality,we aim to address various challenges in asymmetric synthesis. By developing new reactions,strategies,and research domains,we strive to enrich the toolbox of organic chemistry and continually expand its boundaries.

手性是自然界的基本属性之一。组成生命体的DNA、蛋白质等都是手性的；手性化合物如手性药物等在人类社会中的重要性日渐突出。不对称催化是获取手性化合物包括手性药物的重要途径，也是当前有机化学研究中最为活跃也最具挑战性的领域。

本课题组研究领域为不对称催化和药物合成，尤其以多位点羰基分子参与的催化转化为核心，先后开展了三个研究方向的工作：(1) 多位点酮类分子的动力学拆分；(2) 1,2-二酮的高选择性转化；(3) 多位点酯的新反应模式开发。我们注重经验规律的总结同时追求创新和突破，以方法普适性为重要特色，以解决不对称合成中的各类难点为重要目标，开发新反应、新策略、新研究领域，丰富有机化学的工具箱，不断拓展有机化学的边界。

联系方式：

房新强 xqfang@fjirsm.ac.cn, 

0591-63173513，中国科学院福建物质结构研究所高新园区1#1313