报告题目：Enzyme Inspired Ligand Design for Asymmetric Metal Catalysis

报 告 人：Masaya Sawamura教授，北海道大学，日本

时 间：2024/6/11　10:30

地 点：海西院嘉锡楼305报告厅

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个人简介：

Masaya Sawamura课题组致力于发展新型催化剂和有机反应。他通过配体设计在高效催化剂合成和化学反应发展方面取得了杰出成就，在国际知名期刊上发表了200余篇研究论文。Sawamura教授曾获日本化学会奖、名古屋银奖、Negishi奖和日本科学技术表彰奖(MEXT)等奖项。1984: Department of Synthetic Chemistry,Faculty of Engineering,Kyoto University,B.S. (Prof.Tatsuya Shono). 1989: Department of Synthetic Chemistry,Graduate School of Engineering,Kyoto University,Ph.D. (Prof. Yoshihiko Ito). 1993-1994: Visiting Researcher at Harvard University (Prof. Stuart L. Schreiber). 1989-1995: Assistant Professor,Kyoto University (Prof. Y. Ito). 1995: Assistant Professor,Tokyo Institute of Technology (Prof. E. Nakamura). 1995-1996: Assistant Professor,The University of Tokyo (Prof. E. Nakamura). 1996-1997: Lecturer,The University of Tokyo. 1997-2001: Associate Professor,The University of Tokyo. 2001-present: Professor,Department of Chemistry,Faculty of Science,Hokkaido University.

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报告摘要：

经典不对称合成催化剂设计主要关注分子间强相互作用力，如配位作用、氢键相互作用和位阻排斥。近年来计算化学发展揭示了弱分子间相互作用力的重要性，如C–H···O氢键和色散力。在此基础上，前沿催化剂的设计更多考虑了多种分子间相互作用力的协同作用，本报告将讨论不对称催化反应中分子间相互作用的协同影响。

Catalyst design for asymmetric synthesis has generally been done by combining relatively strong intermolecular forces,such as coordinative interactions,hydrogen-bonding interactions,and electrostatic interactions,with repulsive forces called as steric repulsions. On the other hand,recent advancement of computational chemistry has revealed the importance of weak intermolecular forces such as C–H···O hydrogen-bonding and London dispersion,which have not been considered before. As a result,more advanced catalyst design based on the synergistic effect of multiple intermolecular forces including these weak intermolecular forces has become possible,making catalysts more enzyme-like. In this lecture,we will discuss synergistic effects of intermolecular forces in our study of asymmetric catalysis.